The Role of the Nervous System in Neuromuscular Fatigue Induced by Ultra-Endurance Exercise

Ultra-endurance events are not a recent development but they have only become very popular in the last two decades, particularly ultra-marathons run on trails. The present paper reviews the role of the central nervous system (CNS) in neuromuscular fatigue induced by ultra-endurance exercise. Large decreases in voluntary activation are systematically found in ultra-endurance running but are attenuated in ultra-endurance cycling for comparable intensity and duration. This indirectly suggests that afferent feedback, rather than neurobiological changes within the CNS, is determinant in the amount of central fatigue produced. Whether this is due to inhibition from type III and IV afferent fibres induced by inflammation, disfacilitation of Ia afferent fibers due to repeated muscle stretching or other mechanisms still needs to be determined. Sleep deprivation per se does not seem to play a significant role in central fatigue although it still affects performance by elevating ratings of perceived exertion. The kinetics of central fatigue and recovery, the influence of muscle group (knee extensors vs plantar flexors) on central deficit as well as the limitations related to studies on central fatigue in ultra-endurance exercise are also discussed in the present article. To date, no study has quantified the contribution of spinal modulations to central fatigue in ultra-endurance events. Future investigations utilizing spinal stimulation (i.e. thoracic stimulation) must be conducted to assess the role of changes in motoneuronal excitability on the observed central fatigue. Recovery after ultra-endurance events and the effect of sex on neuromuscular fatigue must also be studied further

Assessment of LES-STRIP approach for modeling of droplet dispersion in diesel-like sprays

International audienceIn this paper, the stochastic equations of droplet motion in turbulent flow, proposed recently by Gorokhovski and Zamansky (2018, Phys. Rev. Fluids 3, 3, 034602), are assessed for turbulent spray dispersion in diesel like conditions along with Large Eddy Simulation (LES) for the gaseous flow. For droplets above the Kolmogorov length scale, this model introduces the concept of the stochastic drag, independently of laminar viscosity. For droplets below the Kolmogorov length scale, the model equation does depend on the laminar viscosity through the Stokes drag but the particle motion is stochastically forced. Both the stochastic drag and the stochastic forcing of the Stokes drag equation are based on the simple log-normal stochastic process for the viscous dissipation (ϵ) “seen” along the droplet trajectory. In this paper, this model is applied in the framework of two-way coupling, wherein the turbulence generated by the spray inturn controls the spray dispersion. The criterion for the choice of one of the approaches, i.e., the stochastic drag or the stochastic forcing, follows the classical condition for drag coefficient based on the droplet Reynolds number (Re p). The non-vaporizing spray experiments from Engine Combustion Network (ECN) are used as test cases. In addition to the comparison of the spray penetration length, spreading angle and spray structure with the experimental data, a qualitative analysis of the statistics of the droplet acceleration and gas phase velocities is presented. It was shown that the new approach is much more effective in modeling the spray dynamics on relatively coarser mesh. Consequently, the new approach in the framework of two-way coupling may predict the preferential concentration effects better, which is important for spray combustion

Haptic feedback in teleoperation in Micro-and Nano-Worlds.

International audienceRobotic systems have been developed to handle very small objects, but their use remains complex and necessitates long-duration training. Simulators, such as molecular simulators, can provide access to large amounts of raw data, but only highly trained users can interpret the results of such systems. Haptic feedback in teleoperation, which provides force-feedback to an operator, appears to be a promising solution for interaction with such systems, as it allows intuitiveness and flexibility. However several issues arise while implementing teleoperation schemes at the micro-nanoscale, owing to complex force-fields that must be transmitted to users, and scaling differences between the haptic device and the manipulated objects. Major advances in such technology have been made in recent years. This chapter reviews the main systems in this area and highlights how some fundamental issues in teleoperation for micro- and nano-scale applications have been addressed. The chapter considers three types of teleoperation, including: (1) direct (manipulation of real objects); (2) virtual (use of simulators); and (3) augmented (combining real robotic systems and simulators). Remaining issues that must be addressed for further advances in teleoperation for micro-nanoworlds are also discussed, including: (1) comprehension of phenomena that dictate very small object (< 500 micrometers) behavior; and (2) design of intuitive 3-D manipulation systems. Design guidelines to realize an intuitive haptic feedback teleoperation system at the micro-nanoscale level are proposed

Resting and active motor thresholds versus stimulus–response curves to determine transcranial magnetic stimulation intensity in quadriceps femoris

Background: Transcranial magnetic stimulation (TMS) is a widely-used investigative technique in motor cortical evaluation. Recently, there has been a surge in TMS studies evaluating lower-limb fatigue. TMS intensity of 120-130% resting motor threshold (RMT) and 120% active motor threshold (AMT) and TMS intensity determined using stimulus-response curves during muscular contraction have been used in these studies. With the expansion of fatigue research in locomotion, the quadriceps femoris is increasingly of interest. It is important to select a stimulus intensity appropriate to evaluate the variables, including voluntary activation, being measured in this functionally important muscle group. This study assessed whether selected quadriceps TMS stimulus intensity determined by frequently employed methods is similar between methods and muscles.Methods: Stimulus intensity in vastus lateralis, rectus femoris and vastus medialis muscles was determined by RMT, AMT (i.e. during brief voluntary contractions at 10% maximal voluntary force, MVC) and maximal motor-evoked potential (MEP) amplitude from stimulus-response curves during brief voluntary contractions at 10, 20 and 50% MVC at different stimulus intensities.Results: Stimulus intensity determined from a 10% MVC stimulus-response curve and at 120 and 130% RMT was higher than stimulus intensity at 120% AMT (lowest) and from a 50% MVC stimulus-response curve (p 0.05).Conclusions: Similar optimal stimulus intensity and maximal MEP amplitudes at 20 and 50% MVC and the minimal risk of residual fatigue at 20% MVC suggest that a 20% MVC stimulus-response curve is appropriate for determining TMS stimulus intensity in the quadriceps femoris. The higher selected stimulus intensities at 120-130% RMT have the potential to cause increased coactivation and discomfort and the lower stimulus intensity at 120% AMT may underestimate evoked responses. One muscle may also act as a surrogate in determining optimal quadriceps femoris stimulation intensity

Neuromuscular Fatigability Associated With Different Pacing Strategies During an Ultra-Endurance Pull-Up Task: A Case Study

International Journal of Exercise Science 15(3): 1514-1527, 2022. While neuromuscular fatigability has been previously characterized after running and cycling, no study has investigated an ultra-endurance upper body task. In preparation for a world record attempt, three pacing strategies to perform 1980 pull-ups in 6 hrs were compared during independent sessions: fast pace, long recovery (FL), fast pace, multiple short recoveries (FMS), and slow pace, no recovery (SN). Elbow flexion maximal voluntary contraction (MVC) force, grip strength, peripheral fatigue, and biceps brachii electromyography were quantified every 330 pull-ups and during recovery, alongside heart rate, perceived effort, and arm muscle pain. In all conditions, MVC force decreased rapidly within the first set of 330 pull-ups, with the greatest depression observed in FL (-29.1%) and more gradual declines in FMS (-18.6%) and SN (-8.6%). Similarly, FL displayed the greatest decline in potentiated single twitch (FL: -75.0%; FMS: -53.9%; SN: -41.8%) and high-frequency doublet forces (FL: -63.3%; FMS: -29.2%; SN: -41.8%) following the first set, as well as higher heart rate, effort, and pain throughout the task. Following 24 hrs, MVC force recovered slowest in FL and grip strength recovered fastest in SN. Therefore, for the world record attempt, a strategy with a continuous workload at slower pace should be used

Towards the development of a User Interface to model scenarios on driving Simulators

International audienceScenario Modeling on driving simulator requires careful consideration and controlled environment (depending on the research objectives) to achieve the desired goal of the experiment. It is one of the critical steps while designing and implementing an experiment on a driving simulator. It specifies where and what happens in the simulator by specifying, where to place the virtual objects and what those objects will be doing during the experimental trials. But complex and technical nature of driving simulator makes it difficult for the end-users (behavioral researchers/trainers) to design and execute and experimental protocol

Vibration-induced friction control for walkway locomotion interface

Falls represent a major challenge to mobility for the elderly community, a point that has motivated various studies of balance failures. To support this work, we are interested in mechanisms for the synthesis of ground environments that can be controlled to exhibit dynamic friction characteristics. As a first step, we investigate the design and development of such a variable-friction device, a hybrid locomotion interface using a cable-driven vibrotactile mechanism. Measurements on our prototype, consisting of an aluminum tile covered with low-friction polytetrafluoroethylene (PTFE), demonstrate that it can effectively simulate a low coefficient of static friction. As part of the design, we also investigated the role that induced vibration plays in modifying the coefficient of friction. Measurements of sliding on a PTFE-covered tile in a tilted configuration showed a significant influence of normal low-frequency vibration, particularly for frequencies around 20 Hz, regardless of the user's weight

TREADMILL RUNNING: HOW LONG BEFORE BIOMECHANICS REACH A STEADY STATE?

The purpose of this study was to investigate short-term biomechanical changes during treadmill running and whether footwear influenced this adaptation. Forty-five adults with experience in treadmill running over the last year performed an 8.5-min trial at a self-selected speed with three different midsole hardness. Kinetics, kinematics, soft-tissue vibrations and electromyographic activity were recorded at minutes 0, 2, 4, 6 and 8. The fastest adjustments were an increase of active peak and foot inversion. Step frequency and lower limb stiffness decreased then plateaued at minute 6. Duty factor, contact and flight times didn’t reach a plateau. No time effect was found for passive peak, loading rate, leg muscle activity and soft-tissue vibrations. We recommend a minimum habituation period of 8-minutes to ensure that a maximum of biomechanical parameters reach a steady state

Utilisation de la stimulation magnétique transcrânienne dans l'évaluation de la fonction motrice (aspects méthodologiques et application à l'exercice extrême)

La stimulation magnétique transcrânienne (TMS) est une technique d'investigation classiquement utilisée dans l'évaluation du cortex moteur. La TMS est utilisée dans l'étude de la fatigue afin de distinguer sa composante centrale. Peu d'études ont utilisé cette technique pour évaluer les effets de l'exercice locomoteur et aucune dans des conditions extrêmes. Ainsi, l'objectif de cette thèse était double: d'abord, répondre à certaines questions méthodologiques concernant l'utilisation de la TMS dans l'évaluation de la fatigue, en particulier du muscle quadriceps, et deuxièmement, étudier les effets de l'exercice en conditions extrêmes sur le développement de la fatigue centrale et supraspinal ainsi que sur l excitabilité et l'inhibition corticospinales. Dans les Etudes 1 et 2, l'effet de différentes approches d'une force cible avant l application d'une impulsion TMS ainsi que les différences entre les principales méthodes utilisées pour déterminer l'intensité optimale de TMS ont été étudiés. Dans l'Etude 3, l'effet d'une nuit de privation de sommeil sur les performances cognitives et physiques et les paramètres centraux a été étudié. L'effet d'un ultra-trail de 110 km sur la composante supraspinale de la fatigue centrale a été évalué dans l'Etude 4. Les conclusions principales de cette thèse sont, sur le plan méthodologique, i) que lors de l'évaluation par TMS pendant de brèves contractions volontaires, il est essentiel d appliquer l'impulsion de TMS après que la force produite par le sujet se soit stabilisée à la valeur cible et ii) qu'une courbe stimulus-réponse à 20% de la force maximale volontaire est appropriée pour déterminer l'intensité de TMS optimale dans les études portant sur l'exercice et la fatigue. De plus, bien que la privation de sommeil ait des impacts négatifs sur les performances cognitives et à l'exercice, elle n'a pas d'influence sur des paramètres neuromusculaires ni ne provoque une plus grande fatigue centrale. Une fatigue supraspinale se développe et l excitabilité corticospinale augmente au cours d exercices d'endurance/ultra-endurance en course à pied et ne vélo, tandis que les effets sur les mécanismes inhibiteurs corticospinaux sont équivoques et probablement dépendent des caractéristiques de l'exercice et de l'intensité de la TMSTranscranial magnetic stimulation (TMS) is a widely-used investigative technique in motor cortical evaluation. TMS is now being used in the investigation of fatigue to help partition the effects of central fatigue. Few studies have utilized this technique to evaluate the effects of locomotor exercise and none in conditions of extreme exercise. Therefore, the purpose of this thesis was twofold; first, to answer methodological questions pertaining to the use of TMS in fatigue evaluation, particularly of the quadriceps, and second, to investigate the effects of extreme exercise conditions on the development of central and supraspinal fatigue and corticospinal excitability and inhibition. In Studies 1 and 2, the effect of approaching a target force in different ways before the delivery a TMS pulse and the difference between commonly-employed methods of determining TMS intensity on the selection of optimal TMS intensity were investigated. In Study 3, the effect of one night sleep deprivation on cognitive and exercise performance and central parameters was investigated. The effect of a 110-km ultra-trail on the supraspinal component of central fatigue was evaluated in Study 4. The principal findings from this thesis are that during TMS evaluation during brief voluntary contractions, it is essential to deliver the TMS pulse once the force has stabilized at the target and that a stimulus-response curve at 20% MVC is appropriate for determining optimal TMS intensity in exercise and fatigue studies. Furthermore, while sleep deprivation negatively-impacted cognitive and exercise performance, it did not influence neuromuscular parameters nor result in greater central fatigue. Supraspinal fatigue develops and corticospinal excitability increases during endurance/ultra-endurance running and cycling, while the effects on inhibitory corticospinal mechanisms are equivocal and probably depend on exercise characteristics and TMS intensityST ETIENNE-Bib. électronique (422189901) / SudocSudocFranceF